Table 2.

Unadjusted and adjusted sub-hazard ratios for suicide by use patterns of antidepressants in a national cohort of new users aged 75 and above

Variable	N suicide	Unadjusted SHR (95% CI)	P value	Adjusted SHR (95% CI)a	P value
Early discontinuationb	12	0.74 (0.42–1.32)	0.31	0.82 (0.46–1.42)	0.50
Combination use of ≥ 2 antidepressantsc	16	2.31 (1.39–3.84)	0.001	1.28 (0.74–2.22)	0.38
Switch to another antidepressantd	35	3.37 (2.35–4.82)	< 0.001	2.42 (1.65–3.55)	< 0.001
Medication possession ratio of antidepressants < 80%e	85	1.24 (0.97–1.58)	0.08	1.02 (0.79–1.10)	0.89
Concomitant use of psychotropic medicationsf	241
Hypnotics	207	2.57 (1.99–3.30)	< 0.001	2.20 (1.69–2.85)	< 0.001
Anxiolytics	154	2.18 (1.72–2.77)	< 0.001	1.54 (1.20–1.96)	< 0.001
Antipsychotics	39	1.38 (1.98–1.93)	0.06	1.73 (1.19–2.51)	0.004
Anti-dementia drugs	14	0.43 (0.25–0.73)	0.002	0.72 (0.42–1.24)	0.24
Mood stabilisers	5	0.79 (0.32–1.89)	0.58	0.74 (0.30–1.79)	0.50

.Due to partially missing data, 210 persons were excluded from the regression analysis

SHR sub-hazard ratio

^aAdjusted for age, sex, suicide attempt within 1 year preceding the index date, serious depression, use of statins (a proxy of cardiovascular comorbidity), and nursing home residence

^bReference group: those who did not discontinue their treatment within 180 days following the index date

^cReference group: those who did not combine two antidepressants within 180 days following the index date

^dReference group: those who did not switch to another antidepressant within 180 days following the index date

^eThe proportion of days covered by antidepressant medications during the follow-up period. (Threshold of MPR to define adherence ≥ 80%)

^fReference group: those who did not use the specified psychotropic medication within 90 days following the refill of an antidepressant