Table 2. CSF mutational and therapeutic results.

Patient	CSF-sensitive mutation	CSF T790M	PS	Neurological Findings→Change	CNS radiographic change	Extra-CNS rebiopsy site/T790M status	Extra-CNS response
1	L858R	+	3→1	Abnormal→Improved	Improved	Bone/+	PR
2	Del-19	+	3→1	Abnormal→Improved	Improved	Lung/+	NE
3	Del-19	−	3→3	Abnormal→Stable	Stable	Liver/+	PR
4	Del-19	−	2→2	Abnormal→Stable	Stable	Lymph node/+	NE
5	L858R	−	3→4	Abnormal→Worsened	Progressed	Lung/+	SD
6	−	−	1→1	Normal →Stable	Improved	Pleura/+	PR
7	−	−	2→1	Normal →Stable	Stable	Pleura/+	SD
8	−	−	1→1	Normal →Stable	Improved	Lung/+	PR
9	−	−	1→1	Normal →Stable	Improved	Lung/+	PR
10	−	−	1→1	Abnormal→Improved	Improved	Lung/+	PR
11	−	−	3→1	Abnormal→Improved	Improved	Liver/+	SD
12	−	−	1→1	Normal →Stable	Improved	Pleura/+	PR
13	−	−	1→1	Normal →Stable	NE	Lung/+	PR

Abbreviations: CNS=central nervous system; CSF=cerebrospinal fluid; NE=not evaluable; PR=partial response; PS=performance status; Pt=patient; SD=stable disease.