Figure 1.

The carcinoembryonic antigen‐related cell adhesion molecule (CEACAM) gene superfamily.79 The CEACAM immunoglobulin‐like domain superfamily is a large family of proteins encoded by 12 independent genes and located on chromosome 19. The Ig domain consists generally of one IgV‐like N‐domain (red), except CEACAM 16, which has 2 N‐domains and IgC‐like domains identified as (A and B) shown in (blue). The membrane‐linked glycoproteins are anchored to the cell surface either by transmembrane domain (green zigzag lines), such as CEACAM5‐8, or anchored to the membrane by glycophosphatidyl‐inositol anchor (green arrowhead), including CEACAM1, 3, 4, 19, 20 and 21. CEACAM16 is a secreted version with no membrane anchorage. The CEACAM 19 and 20 cytoplasmic domain has immune‐receptor tyrosine‐based activator (ITAM) motifs (blue circles). Heavily N‐ Glycosylation sites in all family members are shown as black lollipops on the extracellular domains