Table 1.
Patient no. | Stage | Site of metastasis | HPV subtype primary | HPV subtype CTC | No. CTC | No. contaminated WBC | hTERT mRNA expression | Prognosis |
---|---|---|---|---|---|---|---|---|
2 | IIA | no metastasis | 16 | 16 | 2 | 0 | + | NED 40 mo |
4 | Recurrence | Lung | 33 | ND | 4 | 14 | NA | Progression 7 mo, DOD 27 mo |
5 | IB1 | no metastasis | 16 | 16 | 1 | 2 | + | NED 40 mo |
6 | IB1 | no metastasis | 16 | 16 | 3 | 1 | NA | NED 40 mo |
10 | Recurrence | Lung | 16a | 16 | 4 | 5 | NA | Progression 4 mo, DOD 5 mo |
16 | IB1 | no metastasis | 16 | 16 | 1 | 0 | + | NED 29 mo |
DOD, died of disease; HPV, human papillomavirus; hTERT, human telomerase reverse transcriptase; NA, not available; ND, not detected; NED, no evidence of disease; WBC, white blood cells.
The HPV subtype was identified using the AMPLICORE® human papilloma virus test (Roche, Basel, Switzerland).