Figure 3.

Role of Rac GTPase activating protein 1 (RacGAP1) in promoting epithelial ovarian cancer (EOC) cell migration and invasion. A, RNAi efficiency of RacGAP1‐siRNAs was tested by Western blotting, using scrambled siRNA (scram) as the negative control. B, Migration and (C) invasion capacities of OV‐90 cells were upregulated upon RacGAP1‐overexpression (o/e), whereas RacGAP1‐siRNA inhibited cell malignancy. D,E, The same experiments were carried out on another serous EOC cell line, the Caov‐3 cell line, and showed consistent results. All experimental data were from three independent experiments and analyzed by Student's t test. Bar, mean ± standard deviation. *P < .05