Table 2.

SiNE group patient details and treatment outcome

Patient	Breed	Histology	Adam’s stage	Response	Clinical Evaluation
1	Golden Retriever	Adenocarcinoma grade 3	T2	PR	Partial reduction of clinical signs, with a persistent minimum nasal discharge.
2	Miniature Pinscher	Adenocarcinoma grade 2	T2	CR	Complete resolution of clinical signs.
3	Labrador Retriever	Solid carcinoma grade 3	T3	PR	Partial reduction of clinical signs, with persistence of ocular discharge. Death by euthanasia due to distal radius metastasis.
4	Old English Mastiff	Adenocarcinoma grade 2	T4	PR	Complete Resolution of clinical signs.
5	Crossbreed	Squamous cell carcinoma	T2	PR	Partial reduction of clinical signs with persistence of minimum nasal discharge.
6	Labrador Retriever	Round cell sarcoma	T3	PR	Complete resolution of clinical signs.
7	Collie	Sticker sarcoma	T1	CR	Complete resolution of clinical signs.
8	Golden Retriever	Squamous cell carcinoma	T2	PR	Partial reduction of clinical signs, sneezing remains every day with occasional nasal discharge. Death by euthanasia based on the owner’s decision.
9	Spanish Breton	Adenocarcinoma grade 2	T4	SD	No reduction of clinical signs was observed, sneezing remained every day with continuous nasal discharge and persistent inflammation of the subcutaneous tissue and paranasal sinuses. Death by euthanasia based on poor quality of life.
10	Labrador Retriever	Squamous cell carcinoma	T2	PR	Partial reduction of clinical symptoms with occasional sneezing.
11	Golden Retriever	Fibrosarcoma	T2	CR	Complete resolution of clinical signs.