Figure 3.

A. fumigatus ΔatmA and ΔatrA mutants have differential susceptibility to DNA-damaging agents. A. fumigatus wild-type, ΔatmA1, ΔatmA2, ΔatrA1, and ΔatrA2 conidia (1 × 10⁴) were inoculated on MM plus different drug concentrations. (A and B) 4-NQO, (C and D) MMS, (E and F) CPT and (G) Bleomycin or (H) treated with UV light. Plates were incubated for 5 days at 37C. The results were expressed as the average of radial diameter of the treatment divided by the radial diameter of the control of three independent experiments ± SD (* P < 0.001, as determined by Student’s t-tests when comparing the treatment to the control). 4-NQO, 4-nitroquinoline oxide; CPT, camptothecin; MM, minimal media; MMS, methyl methanesulfonate; UV, ultraviolet.