Table 1. The erg11A sequence modifications observed in selected A. fumigatus ΔATM1, ΔATM2, ΔATR1, and ΔATR2 voriconazole-evolved populations.
| Nucleotide Exchange with Amino Acid Change | Nucleotide Exchange Without Amino Acid Change | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Wild-type | Amino acid position | Y46 | V172 | T248 | E255 | K323 | K427 | G89 | L358 | C454 |
| Nucleotide sequence | 136TAT138 | 514GTG516 | 742ACT744 | 763GAG765 | 967AAG969 | 1279AAG1281 | 265GAA267 | 1072TTG1074 | 1360TGC1362 | |
| WTV1 | Amino acid position | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| Nucleotide sequence | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
| ΔATMA1V0 | Amino acid position | ND | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | ND | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATMA1VA | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATMA1VB | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATMA2V0 | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATMA2VC | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATRA2V0 | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATRA2VA | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATRA2VB | Amino acid position | Y46F | V172M | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | 514ATG516 | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
| ΔATRA2VC | Amino acid position | Y46F | ND | T248N | E255D | K323Q | K427E | G89 | L358 | C454 |
| Nucleotide sequence | 136TTT138 | ND | 742AAT744 | 763GAC765 | 967CAG969 | 1279GAG1281 | 265GGG267 | 1072TTA1074 | 1360TGT1362 | |
ND, not different from the erg11A wild-type strain.