Figure 7.

Ion channel profiles of drugs in Parts 1 and 2. Ion channel current effects for drugs in Part 1 (chloroquine, ranolazine, verapamil, lopinavir, and ritonavir) and Part 2 (dofetilide and diltiazem) of the clinical study. Each panel shows relative drug‐induced current block from patch clamp experiments; the error bars represent mean±SE of percentage current block measured in the experiments. Vertical lines represent clinical C_max (solid line) from previous studies and 3‐fold C_max (dashed line). Ion channel data from Crumb et al.19