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Mechanisms of noneosinophilic asthma. CRP = C-reactive protein; CXCR2 = chemokine receptor 2; DAMP = damage-associated molecular patterns; dsRNA = double-stranded RNA; HETE = hydroxyeicosatetraenoic acid; MAPK = mitogen-activated protein kinase; NF-κB = nuclear factor κB; NK = natural killer; sEH = soluble epoxide hydrolase; Tc1 = cytotoxic T-cell subset 1; Th = T-helper cell; TLR4 = toll-like receptor 4; TNFα = tumor necrosis factor-α.
