Figure 4.
Clinical phenotypes, endotypes, and therapeutic options in eosinophilic and noneosinophilic asthma. CRTH2 = chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells; CXCR2 = chemokine receptor 2; DPP4 = dipeptidyl peptidase-4; FeNO = fractional exhaled nitric oxide; GM-CSF = granulocyte–macrophage colony–stimulating factor; ILC = innate lymphoid cell; NK = natural killer; NKT = natural killer-T; PGD2 = prostaglandin D2; PPARγ = peroxisome proliferator-activated receptor-γ; Th = T-helper cell; TNFα = tumor necrosis factor-α; TSLP = thymic stroll lymphopoeitin.