Table 1.

Comparison of Clinical Cluster Analyses in Three Large, Well-phenotyped Asthma Cohorts

SARP Clusters	UBIOPRED Clusters	ADEPT Clusters
1: Early onset, mild, atopic, eosinophilic	US1: Mild asthma, good lung function, early onset, low inflammation	A1: Mild, normal lung function, early onset, low inflammation
2: Early onset, moderate, atopic, eosinophilic	US2: Moderate, hyperresponsive, eosinophilic	A2: Moderate, atopic, mild reversible obstruction, hyperresponsive, eosinophilic
3: Late onset, nonatopic, eosinophilic, female, obese	US3: Mixed severity, mild reversible obstruction, noneosinophilic, neutrophilic	A3: Mixed severity, mild reversible obstruction, noneosinophilic, neutrophilic
4: Early onset, severe, atopic, reversible obstruction, eosinophilic	US4: Severe uncontrolled, severe reversible obstruction, mixed granulocytic	A4: Severe uncontrolled, severe reversible obstruction, mixed granulocytic
5: Late onset, long duration, severe, fixed airflow obstruction

Definition of abbreviations: ADEPT = Airways Disease Endotyping for Personalized Therapeutics; SARP = Severe Asthma Research Program; UBIOPRED = Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium.