Table 1.
Research Site* | No. of Subjects | Consortium Lung Phenotype† (Mean ± SD) | Age at Consortium Lung Phenotype† (yr) (Median; Range) | Male Sex (%) | BMI (Mean ± SD) | Pseudomonas aeruginosa Infection‡ (%) | CFRD§ (%) | European|| (%) | Phe508del Homozygous (%) |
---|---|---|---|---|---|---|---|---|---|
CWRU | 38 | 0.9 ± 0.9 | 24.3; 11.4–49.2 | 46 | 21.8 ± 3.3 | 90 | 48 | 98 | 79 |
JHU | 17 | 1.2 ± 0.8 | 27.1; 18.3–47.3 | 49 | 22.2 ± 3.7 | 92 | 30 | 100 | 77 |
TOR | 35 | 0.8 ± 0.6 | 23.1; 10.4–42.6 | 63 | 22.0 ± 3.8 | 78 | 23 | 97 | 100 |
UNC | 44 | 0.7 ± 0.8 | 23.8; 11.6–49.5 | 53 | 21.9 ± 3.8 | 91 | 35 | 100 | 100 |
Total | 134 | 0.8 ± 0.8 | 26.5; 10.4–49.5 | 52 | 21.8 ± 3.3 | 86 | 35 | 99 | 91 |
Definition of abbreviations: BMI = body mass index; CFRD = cystic fibrosis–related diabetes; CWRU = Case Western Reserve University; JHU = Johns Hopkins University; KNoRMA = Kulich Normal Residual Mortality Adjusted; TOR = University of Toronto; UNC = University of North Carolina.
See Methods section of online supplement for participating sites and enrollment information.
Subjects were defined by the quantitative Consortium lung phenotype (KNoRMA) value (8).
Positive lower respiratory culture within 2 years preceding study enrollment; percentage noted is based on data available for 94 subjects.
CFRD percentage noted is based on data available for 117 subjects.
Based on self-identified ancestry and principal component analysis via SNP genotypes.