Figure 3.

Preventive effects of Alda-1 on acrolein-induced lung edema and inflammation. Mice were administered Alda-1 (10 mg/kg) or an equal volume of sterilized saline (control) via intraperitoneal injection. After 1 hour, the mice were intratracheally administered 2.5 mg/kg of acrolein or an equal volume of sterilized saline. BAL protein levels (A), BAL cell count (B), lung wet-to-dry weight ratio (C), and changes in mouse body weights (D) were assessed 18 hours after challenge with acrolein. Some mice were treated first with acrolein for 2 hours, followed by Alda-1 (C). Three to four mice per group were used for each panel. Data are represented as means ± SE. *P < 0.05 versus mice treated with saline control, ^£P < 0.05 versus mice treated with acrolein alone.