Figure 4.

Induction of AAD by ovalbumin (OVA) inoculation is IgE-independent. WT and IgE-deficient FVB/N mice were injected three times intraperitoneally, once every 3 days, with 50 μg of OVA, then inoculated intranasally weekly with 20 μg of OVA for 9 weeks. (A and B) AHR and pulmonary eosinophilia, respectively; n = 11–12/group pooled from two experiments. Mice per each experimental group from left to right: 12, 12, 11, and 12. FVB/N WT, blue bars; FVB/N IgE-knockout, red bars. *P < 0.05. Data presented are means (±SEM).