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Exogenous 15-HETE-PE stimulation induces FOXA3, MUC5AC, and periostin expression in HAECs in the absence of IL-13. HAECs under air–liquid interface culture were stimulated with 1 μM 15-HETE-PE for 5 days, with dimyristoyl-phosphatidylethanolamine (DMPE) applied as vehicle control. 15-HETE-PE induced FOXA3 (A and B), MUC5AC (C and D), and periostin (B and E) but had no effect on FOXA2 (F). Data are presented as means ± SEM, analyzed by paired t test.
