Table 7. Relative Receptor-Blocking Effects of Antidepressants.

ANTIDEPRESSANT	ACH	?1	H1	5-HT1	5-HT2
amitriptyline	+++	+++	++	+/–	+/–
amoxapine	+	++	+	+/–	+++
bupropion	0	0	0	0	0
citalopram/escitalopram	0	0	0	0	0
clomipramine	+	++	+	0	+
desipramine	+	+	+	0	+/–
doxepin	++	+++	+++	+/–	+/–
fluoxetine	0	0	0	0	+/–
fluvoxamine	0	0	0	0	0
imipramine	++	+	+	0	+/–
maprotiline	+	+	++	0	+/–
mirtazapine	0	0	+++	+	+
nefazodone	0	+	0	+	++
nortriptyline	+	+	+	+/–	+
paroxetine	+	0	0	0	0
protriptyline	+++	+	+	0	+
sertraline	0	0	0	0	0
trazodone	0	++	+/–	+	++
trimipramine	++	++	+++	0	+/–
venlafaxine	0	0	0	0	0

Note: Data are approximations of relative activity from in vivo, in vitro, and clinical studies.

ACh = muscarinic acetylcholine receptor; α₁ = α₁-adrenergic receptor, H₁ = histamine₁ receptor; 5-HT₁ = serotonin₁ receptor; 5-HT₂ = serotonin₂ receptor. Strength of effect represented on scale from 0 (no effect) to +++ (marked effect). +/– indicates marginal effect.