2.

Cox regression analysis of overall survival and patient characteristics

Variable	Univariate			Multivariate
	RR (95%CI)	P		RR (95%CI)	P
RR: relative risk; 95%CI: 95% confidence interval
Age	1.53 (1.06–2.20)	0.023		1.51 (0.96–2.37)	0.077
Gender
Male	1.00	0.672		1.00	0.484
Female	1.08 (0.75–1.56)			0.80 (0.44–1.48)
Smoking status
No	1.00	0.241		1.00	0.211
Yes	0.80 (0.56–1.16)			0.67 (0.36–1.26)
Stage
I–II	1.00	< 0.001		1.00	< 0.001
III–IV	4.18 (2.86–6.10)			3.44 (2.18–5.44)
Family history of cancer
No	1.00	0.341		1.00	0.519
Yes	1.25 (0.79–1.97)			1.21 (0.68–2.17)
TMEM88 methylation
Low	1.00	0.021		1.00	0.018
High	1.57 (1.07–2.38)			1.74 (1.10–2.74)
TMEM88 expression
Low	1.00	0.521		1.00	0.940
High	0.88 (0.60–1.30)			0.98 (0.63–1.53)