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. 2017 Nov 6;82(5):729–743. doi: 10.1002/ana.25073

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© 2017 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Therapeutic treatment with metoprolol after right transient middle cerebral artery occlusion (tMCAO) prevents development of systolic dysfunction. (A–F) Hemodynamic parameters of vehicle‐ or metoprolol‐treated mice assessed 8 weeks after tMCAO: heart rate (A), ejection fraction (B), heart weight (HW)/lung weight (LW) to body weight (BW) ratio (C), end‐systolic and end‐diastolic left ventricular (LV) volume (D), end‐systolic and end‐diastolic LV pressure (E), and representative pressure–volume loops in vehicle (red) and metoprolol‐treated mice (black; F). (G) Time course of fractional shortening of vehicle‐ or metoprolol‐treated C57BL/6J mice after tMCAO (n = 9–11 animals per group for all experiments; *p < 0.05, **p < 0.01, ***p < 0.001).