Figure 5:

Examples of lncRNA-associated molecular components uncovered by circlncRNAnet. circlncRNAnet may be used to extensively profile the molecular interactome of candidate circRNAs/lncRNAs based on the compiled databases, with ELFN1-AS1 shown as an example in this figure. (A) For the RBP components, the interactome will be outputted in both the table format (top) and network configuration (bottom). (B) Similarly, for the putative miRNA sponge network, predicted ELFN1-AS1-targeting miRNAs are shown in table (top) and network (bottom) formats. The web server is also designed to construct the ncRNA-RBP-mRNAs or ncRNA-miRNA-mRNAs regulatory hierarchy. circlncRNAnet delineates co-expressed mRNA genes with mutually shared RBP binding or miRNA targeting sites. Consequently, an intersected gene list is compiled (top) and may be depicted in a 2-tier network configuration (bottom).