Table 1.
Differentially regulated matrix metalloproteinases and their inhibitors using genome-wide transcription profile of scar biopsies with or without 14-day compression treatment*
| Sham | Compression treated | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wound and scar | 2 wk of device with no pressure | Wound and scar | 2 wk device/30 mm Hg pressure, device removed | |||||||||
| Early | Mid | Late | Early | Mid | Late | |||||||
| Metallo-proteases/inhibitor type | log FC | P | log FC | P | log FC | P | log FC | P | log FC | P | log FC | P |
| MME | −0.109 | 7.70E-01 | −0.205 | 6.38E-01 | −1.137 | 1.39E-02 | −0.208 | 5.81E-01 | −0.554 | 2.10E-01 | −0.674 | 1.30E-01 |
| MMP1 | 0.063 | 9.27E-01 | −0.574 | 4.15E-01 | 0.584 | 4.07E-01 | −0.402 | 5.63E-01 | 0.208 | 7.67E-01 | −0.457 | 5.15E-01 |
| MMP2 | 1.614 | 5.52E-06 | 0.811 | 2.11E-02 | 1.07 | 3.32E-03 | 1.748 | 2.51E-06 | 1.215 | 1.10E-03 | 0.761 | 2.95E-02 |
| MMP3 | −0.661 | 2.75E-01 | −0.628 | 3.15E-01 | −0.989 | 1.19E-01 | 0.13 | 8.25E-01 | 0.011 | 9.86E-01 | −0.28 | 6.52E-01 |
| MMP7 | −1.308 | 3.44E-01 | −4.488 | 1.74E-04 | −5.816 | 6.01E-06 | −2.72 | 6.37E-02 | −4.9 | 6.10E-05 | −4.982 | 4.95E-05 |
| MMP9 | 2.04 | 5.15E-02 | 1.651 | 3.21E-01 | 2.523 | 5.81E-03 | 1.966 | 5.93E-02 | 0.902 | 2.92E-01 | 1.04 | 2.25E-01 |
| MMP11 | 3.986 | 9.23E-05 | 1.9 | 1.99E-02 | 1.401 | 3.04E-02 | 4.162 | 6.30E-05 | 2.464 | 4.48E-04 | 1.536 | 1.86E-02 |
| MMP12 | 1.09 | 5.60E-01 | 0.861 | 7.06E-01 | 2.737 | 2.37E-01 | 0.806 | 6.65E-01 | 0.676 | 7.67E-01 | 1.148 | 6.16E-01 |
| MMP14 | 3.188 | 1.10E-07 | 1.89 | 6.15E-04 | 1.895 | 6.01E-04 | 3.588 | 3.11E-08 | 2.166 | 1.40E-04 | 1.196 | 2.04E-02 |
| MMP15 | 0.898 | 3.99E-02 | 0.046 | 9.21E-01 | 0.225 | 6.28E-01 | 0.985 | 2.66E-02 | 0.572 | 2.24E-01 | 0.376 | 4.19E-01 |
| MMP16 | 1.878 | 7.59E-05 | 0.328 | 6.04E-01 | 0.607 | 3.40E-01 | 1.7 | 1.80E-04 | 0.946 | 1.43E-01 | 0.799 | 2.13E-01 |
| MMP19 | 0.888 | 4.37E-02 | 0.795 | 4.31E-02 | 0.459 | 2.30E-01 | 0.474 | 2.51E-01 | 1.053 | 9.17E-03 | 1.124 | 5.81E-03 |
| MMP23B | 1.292 | 5.96E-04 | 0.07 | 8.80E-01 | 1.063 | 2.93E-02 | 1.346 | 4.30E-04 | 1.06 | 2.98E-02 | −0.024 | 9.59E-01 |
| MMP25 | −0.66 | 1.63E-01 | −0.711 | 4.07E-02 | −0.705 | 4.22E-02 | −0.793 | 9.95E-02 | −0.637 | 6.46E-02 | −0.761 | 2.95E-02 |
| TIMP1 | 1.872 | 5.64E-08 | 1.243 | 7.30E-03 | 1.413 | 2.76E-03 | 1.835 | 6.97E-08 | 1.542 | 1.29E-03 | 0.942 | 3.62E-02 |
| TIMP2 | 1.892 | 8.17E-08 | 0.969 | 1.63E-02 | 1.467 | 6.45E-04 | 2.03 | 3.85E-08 | 1.207 | 3.65E-03 | 0.346 | 3.67E-01 |
| A2M | 0.067 | 8.63E-01 | 0.482 | 3.89E-01 | 0.069 | 9.01E-01 | −0.231 | 5.57E-01 | 0.083 | 8.81E-01 | −0.238 | 6.69E-01 |
*Biopsy specimens were collected over 133 days postwound and combined in 3 wound-healing stages, early, mid, and late, for analysis. Reported values are the log2 fold change. Significant fold change (>1.3 FC and/or P < .05) in at least 1 time point. FC indicates fold change.