Fig. 1.

Sitagliptin reduced hyperglycemia and glucose intolerance in GK rats. a Body weight and plasma parameters were evaluated in the experimental model. TG, triglycerides; Ch, cholesterol, LDL and HDL, low- and high-density lipoproteins, respectively, and FFA, free FA. N = 10, each group. b Plasma glucose, insulin and GLP-1 were measured in fasting rats before (0 min) and after (15–60 min) an oral glucose loading (G). *p < 0.05 and **p < 0.01 vs. wistar. ^†p < 0.05 and ^††p < 0.01 vs. GK rats. ^§p < 0.05 vs. 15 min glucose-overload or fasting state. N = 7, each group