Table 1.

Clinical assessments for CAD patients in CCADS

Domain	Assessment
Demographics	age, gender, educational level, contact information
Medical history
vascular risk factors	American Heart Association guideline [21]
migraine	classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain [22]
I CTD*	Ehlers-Danlos syndrome, Marfan Syndrome, Loeys-Dietz syndrome, etc. [23]
autoimmune diseases	SLE, Becet’s disease, Sjogren’s syndrome, etc.
mild trauma	neck manipulation or overextension (within 2 weeks prior to symptom onset) [24]
infection	within 2 weeks prior to symptom onset
Personal history
smoking	a structured questionnaire embedded in CRF
alcohol use	a structured questionnaire embedded in CRF
risk factor control	hypertension, migraine, etc.
Clinical presentations
stroke	clinical stroke syndrome (sudden neurological dysfunction lasting >24 h, with no apparent cause other than that of vascular origin)
TIA	rapidly evolving focal neurological deficit, without positive phenomena such as twitches, jerks or myoclonus, with no other than vascular cause lasting less than 24 h
cranial nerve palsy	peripheral hypoglossal nerve or facial nerve palsy
headache	new onset headache; severity, nature, location or frequency change
Horner syndrome	Miosis, partial ptosis, loss of hemifacial sweating
stroke severity	NIHSS [25]
stoke risk after TIA	ABCD2 scores [26]
Functional independence	mRS [27]
Treatment
antithrombotic drugs	aspirin, clopidogrel, NOAC
reperfusion therapy	intravenous thrombolysis, intra-arterial thrombolysis, endovascular intervention
other medicines	statin, antihypertensive therapy, antidiabetics
medication compliance	a structured questionnaire
time	time from symptom onset to treatment, and treatment duration

*ICTD Inherited connective tissue disorders, mRS Modified Rankin Scale, NIHSS National Institute of Health Stroke Scale, TIA Transient ischemic attack, NOAC Novel oral anticoagulant, SLE Systemic lupus erythematosus