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Gross morphological and histological examination of CIA. (A) Gross observation of mouse paws. Shown are the fore paws (top) and hind paws (bottom) of control (n = 12) and CIA (n = 14) mice at 14 weeks of age. Scale bars = 10 mm. (B) H&E staining of sagittal sections of control and CIA mouse joints. Lower panels show enlarged views of the areas delineated by a box in the upper panels. Arrows indicate cartilage boundaries. Scale bars = 1 mm.
