Table 2.
KEGG pathway analysis of differentially expressed genes identified by microarray analysis
| No. | KEGG classification | Pathway | Number of significant genes | Increased genes | Decreased genes | P value |
|---|---|---|---|---|---|---|
| 1 | Immune system | Th1 and Th2 cell differentiation | 7 | Stat4, Lck, Il2rb, Cd4, Lat, Cd3e, Cd3g | < 0.001 | |
| 2 | Th17 cell differentiation | 6 | Lck, Il2rb, Cd4, Lat, Cd3e, Cd3g | < 0.001 | ||
| 3 | T cell receptor signaling pathway | 6 | Lck, Cd4, Lat, Cd3e, Cd3g, Cd8b1 | < 0.001 | ||
| 4 | Antigen processing and presentation | 5 | H2-Q8, H2-T24 | Klrd1, Cd4, Cd8b1 | < 0.001 | |
| 5 | Hematopoietic cell lineage | 5 | Il7r, Cd4, Cd3e, Cd3g, Cd8b1 | < 0.001 | ||
| 6 | Complement and coagulation cascades | 5 | C1ra, Vwf, F5, C3 | Cd59a | < 0.001 | |
| 7 | Natural killer cell mediated cytotoxicity | 4 | Klrd1, Lck, Ncr1, Lat | < 0.001 | ||
| 8 | NOD-like receptor signaling pathway | 4 | Irf7, Oas3, Ifi204 | Ccl5 | < 0.01 | |
| 9 | RIG-I-like receptor signaling pathway | 3 | Irf7, Isg15, Ifih1 | < 0.01 | ||
| 10 | Immune diseases | Primary immunodeficiency | 5 | Lck, Il7r, Cd4, Cd3e, Cd8b1 | < 0.001 | |
| 11 | Systemic lupus erythematosus | 5 | Hist1h2bj, Hist1h2aa, C3, Hist2h4 | Hist1h2ba | < 0.001 | |
| 12 | Graft-versus-host disease | 3 | H2-Q8, H2-T24 | Klrd1 | < 0.01 | |
| 13 | Signal transduction | PI3K-Akt signaling pathway | 10 | Fn1, Itga2, Vwf, Thbs1 | Pck2, Ppp2r2d, Itgb7, Ccnd2, Il7r, Il2rb | < 0.001 |
| 14 | Jak-STAT signaling pathway | 4 | Stat4, Ccnd2, Il7r, Il2rb | < 0.01 | ||
| 15 | MAPK signaling pathway | 4 | Dusp3, Rps6ka2, Fos, Flna | < 0.01 | ||
| 16 | NF-kappa B signaling pathway | 3 | Bcl2a1c, Lck, Lat | < 0.05 | ||
| 17 | Signaling molecules and interaction | Cell adhesion molecules (CAMs) | 5 | H2-Q8, H2-T24 | Itgb7, Cd4, Cd8b1 | < 0.001 |
| 18 | ECM-receptor interaction | 4 | Fn1, Itga2, Vwf, Thbs1 | < 0.001 | ||
| 19 | Cytokine-cytokine receptor interaction | 4 | Il7r, Il2rb, Ccl5, Cd27 | < 0.01 | ||
| 20 | Cellular community | Focal adhesion | 6 | Fn1, Vcl, Itga2, Vwf, Flna, Thbs1 | < 0.001 | |
| 21 | Cell growth and death | Apoptosis | 4 | Tuba3b, Spta1 | Bcl2a1c, Ctsw | < 0.01 |
| 22 | Transport and catabolism | Phagosome | 9 | H2-Q8, C1ra, Tuba3b, H2-T24, Itga2, C3, Thbs1 | Sec61b, Cd209a | < 0.01 |
| 23 | Lipid metabolism | alpha-Linolenic acid metabolism | 2 | Fads2, Pla2g2a | < 0.05 | |
| 24 | Translation | Ribosome | 7 | Rps15 | Rps2, Rpl30,Rpl37a, Rpl6, Rps11, Rps8 | < 0.01 |
| 25 | Nervous system | Neurotrophin signaling pathway | 3 | Rps6ka2, Sort1, Ptpn11 | < 0.05 | |
| 26 | Sensory system | Olfactory transduction | 12 | Clca3a1, Olfr774, Olfr1386, Olfr1502, Olfr726, Olfr1298, Olfr38 | Olfr1299,Olfr1501, Olfr705, Olfr373, Olfr875 | < 0.001 |