Table 3A.
Proteins differentially expressed in the blood of control and CIA mice. (A) Classification of upregulated proteins
| No. | Classification | Identified proteins | Number of proteins |
|---|---|---|---|
| 1 | Cytokine-cytokine receptor interaction | IL-2, IL-27, IL-17, MIP-1beta, IL-23, IL-1beta, IL-1ra, MIP-2, MCP-5, TARC, IL-3, TNF-alpha, IP-10, MIG, BLC, I-TAC, RANTES, IL-4, IL-6, IL-5, IL-10 | 21 |
| 2 | Jak-STAT signaling pathway | IL-2, IL-27, IL-23, IL-3, IL-4, IL-6, IL-5, IL-10 | 8 |
| 3 | Th17 cell differentiation | IL-2, IL-27, IL-17, IL-23, IL-1beta, IL-1ra, IL-4, IL-6 | 8 |
| 4 | Rheumatoid arthritis | IL-17, IL-23, IL-1beta, MCP-5, TNF-alpha, RANTES, IL-6, IL-16 | 7 |
| 5 | Hematopoietic cell lineage | IL-1beta, IL-1ra, IL-3, TNF-alpha, IL-4, IL-6, IL-5 | 7 |
| 6 | NOD-like receptor signaling pathway | IL-1beta, MIP-2, MCP-5, TNF-alpha, RANTES, IL-6 | 6 |
| 7 | Graft-versus-host disease | IL-2, IL-1beta, TNF-alpha, IL-6, IL-10 | 5 |
| 8 | NF-kappa B signaling pathway | MIP-1beta, IL-1beta, IL-1ra, TNF-alpha, BLC | 5 |
| 9 | T cell receptor signaling pathway | IL-2, TNF-alpha, IL-4, IL-5, IL-10 | 5 |
| 10 | PI3K-Akt signaling pathway | IL-2, IL-3, IL-4, IL-6 | 4 |
| 11 | Th1 and Th2 cell differentiation | IL-2, IL-4, IL-5 | 3 |
| 12 | MAPK signaling pathway | IL-1beta, IL-1ra, TNF-alpha | 3 |
| 13 | Systemic lupus erythematosus | TNF-alpha, IL-10 | 2 |
| 14 | HIF-1 signaling pathway | TIMP-1, IL-6 | 2 |
| 15 | RIG-I-like receptor signaling pathway | TNF-alpha, IP-10 | 2 |
| 16 | Apoptosis | IL-3, TNF-alpha | 2 |
| 17 | Natural killer cell mediated cytotoxicity | TNF-alpha | 1 |
| 18 | Antigen processing and presentation | TNF-alpha | 1 |