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. 2018 Jan 1;15(1):77–85. doi: 10.7150/ijms.22345

Table 3A.

Proteins differentially expressed in the blood of control and CIA mice. (A) Classification of upregulated proteins

No. Classification Identified proteins Number of proteins
1 Cytokine-cytokine receptor interaction IL-2, IL-27, IL-17, MIP-1beta, IL-23, IL-1beta, IL-1ra, MIP-2, MCP-5, TARC, IL-3, TNF-alpha, IP-10, MIG, BLC, I-TAC, RANTES, IL-4, IL-6, IL-5, IL-10 21
2 Jak-STAT signaling pathway IL-2, IL-27, IL-23, IL-3, IL-4, IL-6, IL-5, IL-10 8
3 Th17 cell differentiation IL-2, IL-27, IL-17, IL-23, IL-1beta, IL-1ra, IL-4, IL-6 8
4 Rheumatoid arthritis IL-17, IL-23, IL-1beta, MCP-5, TNF-alpha, RANTES, IL-6, IL-16 7
5 Hematopoietic cell lineage IL-1beta, IL-1ra, IL-3, TNF-alpha, IL-4, IL-6, IL-5 7
6 NOD-like receptor signaling pathway IL-1beta, MIP-2, MCP-5, TNF-alpha, RANTES, IL-6 6
7 Graft-versus-host disease IL-2, IL-1beta, TNF-alpha, IL-6, IL-10 5
8 NF-kappa B signaling pathway MIP-1beta, IL-1beta, IL-1ra, TNF-alpha, BLC 5
9 T cell receptor signaling pathway IL-2, TNF-alpha, IL-4, IL-5, IL-10 5
10 PI3K-Akt signaling pathway IL-2, IL-3, IL-4, IL-6 4
11 Th1 and Th2 cell differentiation IL-2, IL-4, IL-5 3
12 MAPK signaling pathway IL-1beta, IL-1ra, TNF-alpha 3
13 Systemic lupus erythematosus TNF-alpha, IL-10 2
14 HIF-1 signaling pathway TIMP-1, IL-6 2
15 RIG-I-like receptor signaling pathway TNF-alpha, IP-10 2
16 Apoptosis IL-3, TNF-alpha 2
17 Natural killer cell mediated cytotoxicity TNF-alpha 1
18 Antigen processing and presentation TNF-alpha 1