TABLE 3.
Clinical characteristics of published transplant recipients with donor-derived WNV infection
| Characteristic (No. of recipients with data) | |
|---|---|
| No. of transplant recipients | 20 |
| Age (14) | |
| Mean (range), yr | 52 (25–73) |
| Median (range), yr | 52 (25–73) |
| Sex (20) | |
| Male | 10 |
| Female | 4 |
| Not reported | 6 |
| Type of transplant (20) | |
| Kidney | 9 |
| Liver | 6 |
| Lung | 3 |
| Heart | 2 |
| Immunosuppresive agents (13) | |
| Tacrolimus | 12 |
| Corticosteroids | 11 |
| Mycophenolate | 10 |
| Antilymphocyte antibodies | 7 |
| Cyclosporine | 1 |
| Sirolimus | 1 |
| Days from transplant to symptoms (15) | |
| Mean (range), d | 14 (5–37) |
| Median (range), d | 13 (5–37) |
| Clinical WNV diagnosis (20) | |
| Encephalitis | 14 |
| WNV fever | 1 |
| Asymptomatic | 5 |
| Initial symptoms (15) | |
| Fever, constitutional symptoms | 10 |
| Fever, dyspnea | 1 |
| Fever, altered mental status | 1 |
| Altered mental status | 1 |
| Encephalopathy | 2 |
| Seizures | 1 |
| Neurological symptoms in patients with WNV encephalitis (11) | |
| Altered mental status | 11 |
| Dysarthria | 4 |
| Lower extremity weakness | 4 |
| Flaccid paralysis | 5 |
| Hemiparesis | 2 |
| Facial nerve palsy | 1 |
| Seizures | 4 |
| Coma | 8 |
| WNV testing of serum | |
| Positive serum PCR | 10/12a |
| Positive serum IgM | 15/18 |
| Positive serum IgG | 5/8 |
| Positive tissue PCR (brain) | 2/2 |
a
No. of transplant recipients positive/no. of transplant recipients tested.
WNV, West Nile virus; PCR, polymerase chain reaction.