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. Author manuscript; available in PMC: 2019 Jan 9.
Published in final edited form as: Cell Metab. 2018 Jan 9;27(1):180–194.e6. doi: 10.1016/j.cmet.2017.12.005

Figure 6. GTF2IRD1-mediated repression of adipose fibrosis is associated with improved systemic glucose homeostasis independent of body-weight.

Figure 6

(A) Body-weight gain of Gtf2ird1 Tg mice and the littermate controls (control) under HFD at 22°C. n=15. * P<0.05.

(B) GTT in Gtf2ird1 Tg mice and controls after 10 weeks of HFD at 22°C. n=6–7.

(C) ITT in Gtf2ird1 Tg mice and controls after 10 weeks of HFD at 22°C. n=6–7.

(D) Serum concentrations of fasting insulin in Gtf2ird1 Tg mice and controls after 11 weeks of HFD. n=6–8.

(E) Relative mRNA expression of pro-fibrosis genes in the inguinal WAT of Gtf2ird1 Tg mice and controls after 11 weeks of HFD. n=6. * P<0.05, ** P<0.01.

(F) Relative mRNA expression of pro-inflammatory genes in the inguinal WAT of Gtf2ird1 Tg mice and controls after 11 weeks of HFD. n=6.

(G) Body-weight gain of Gtf2ird1 Tg mice and controls under HFD under thermoneutrality (30°C). n=9–15.

(H) GTT in Gtf2ird1 Tg mice and controls after 10 weeks of HFD under thermoneutrality. n=6–7.

(I) Hydroxyproline content in the BAT (left) and the inguinal WAT (right) from Gtf2ird1 Tg mice and controls after 12 weeks of HFD under thermoneutrality. n=6–7. All the data are presented as means ± SEM.