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. 2017 Jul 17;45(16):9229–9243. doi: 10.1093/nar/gkx616

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Published by Oxford University Press on behalf of Nucleic Acids Research 2017.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 7. — Explanation of the dyad identification algorithm as applied to 601TA-NUC nucleosome with known dyad position. (A) Pearson correlation coefficient between top (TS) and (BS) strand experimental HRF profiles as a function of putative dyad position used for the alignment of these profiles. The real dyad position corresponds to one of the local maxima. Only every other local maxima is compatible with a stereochemically allowed solution (‘3:7 rule’). (B) Superposition of TS and BS profiles aligned using the real (known) position of the dyad. (C) Superposition of TS and BS profiles aligned using a stereochemically forbidden putative dyad position.