Fig. 4.
Genetic deletion of p47phox inhibits Nf1+/− neointima formation. Representative photomicrographs (A) and quantification of neointima area (B and C) of injured carotid arteries from WT, Nf1+/−, and Nf1+/−;p47phox−/− mice. A. Black arrows indicate neointima boundaries. Black boxes identify area of injured artery that is magnified below. Scale bars: 100μm. B and C. Quantification of neointima area (B) and I/M ratio (C) of injured carotid arteries from WT, Nf1+/−, and Nf1+/−;p47phox−/− mice. Data represent mean neointima area or I/M ratio±SEM, n=8–11. *P<0.001 for WT and Nf1+/−;p47phox−/− mice versus Nf1+/− mice.