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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2017 Sep 27;16(12):2892–2901. doi: 10.1158/1535-7163.MCT-17-0170

Figure 2.

Figure 2

Chemical structures of A, veliparib, B, olaparib, C, talazoparib. D, IC50 values for veliparib, olaparib, and talazoparib compiled for 8 breast cancer cell lines. Average values for triplicate wells and replicate assays were used. Error bars refer to standard error of the mean of replicate assays. Light grey bars refer to BRCA-mutant cell lines, while dark grey bars refer to BRCA wild-type cell lines. Grey arrows refer to plasma concentrations of the PARP inhibitors achieved in patients. N/A refers to not available.