FIGURE 2. Resident cytolytic type 1 innate lymphocytes in the tumor microenvironment.

These cells express high levels of Tbet, low levels of Eomes, and proliferate in the setting of the tumor. They have cytotoxic potential directly against tumor cells. The tumor microenvironment may modulate the responses of these cells through the cytokines IL-15 and TGF-β and through ligands for NK receptors, including stress-associated molecules, which can be either surface-bound or shed.