Table 1.

(Step 1) Clinical trial evidence types represented in DIDEO, their textual definitions, and their necessary and sufficient conditions.

Evidence type (IRI and rdfs:label)	Definition (iao:definition)	Axiom
DIDEO_00000056 evidence information from clinical study	An evidence information content entity that is about a clinical drug trial.	‘evidence information content entity’ and (‘is about’ some (assay and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some (‘chemical entity’ or ‘drug product’))))
DIDEO_00000071 evidence information from drug-drug interaction clinical trial	An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input.	‘evidence information content entity’ and (‘is about’ some (‘scientific observation’ and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘is bearer of’ some ‘object drug role’))) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘is bearer of’ some ‘precipitant drug role’)))))
DIDEO_00000072 evidence information from non-randomized drug-drug interaction clinical trial	An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input.	‘evidence information content entity’ and (‘is about’ some (assay and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘bearer of’ some ‘object drug role’))) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘bearer of’ some ‘precipitant drug role’)))))
DIDEO_00000073 evidence information from parallel groups drug-drug interaction clinical trial’	An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input, and that does not have group randomization as a part, and that realizes a clinical study design that has parallel group design as a part.	‘evidence information content entity’ and (‘is about’ some (‘scientific observation’ and (not (has_part value ‘group randomization’)) and (realizes some (concretizes some (‘clinical study design’ and (has_part some ‘independent measure design’)))) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘is bearer of’ some ‘object drug role’))) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘is bearer of’ some ‘precipitant drug role’)))))
DIDEO_00000074 evidence information from randomized drug- drug interaction clinical trial	An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input and does have group randomization as a part.	‘evidence information content entity’ and (‘is about’ some (‘scientific observation’ and (has_part some ‘group randomization’) and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘is bearer of’ some ‘object drug role’))) and (has_specified_input some ((‘chemical entity’ or ‘drug product’) and (‘is bearer of’ some ‘precipitant drug role’)))))
DIDEO_00000075 evidence information from pharmacokinetic trial	An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics.	‘evidence information content entity’ and (‘is about’ some (‘scientific observation’ and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some (organism and (participates_in some ‘pharmacokinetic process’))) and (has_specified_input some (‘chemical entity’ or ‘drug product’))))
DIDEO_00000076 evidence information from genotyped pharmacokinetic trial	An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics and that has organisms as participants that participated in genotyping.	‘evidence information content entity’ and (‘is about’ some (‘scientific observation’ and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some (organism and (participates_in some ‘pharmacokinetic process’) and (participates_in some genotyping))) and (has_specified_input some (‘chemical entity’ or ‘drug product’))))
DIDEO_00000103 evidence information from phenotyped pharmacokinetic trial	An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics and that has organisms as participants that participated in phenotyping.	‘evidence information content entity’ and (‘is about’ some (‘scientific observation’ and (realizes some (concretizes some ‘clinical study design’)) and (has_specified_input some (organism and (participates_in some ‘pharmacokinetic process’) and (participates_in some ‘phenotype characterization’))) and (has_specified_input some (‘chemical entity’ or ‘drug product’))))