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. Author manuscript; available in PMC: 2019 Jan 8.
Published in final edited form as: Cancer Cell. 2018 Jan 8;33(1):125–136.e3. doi: 10.1016/j.ccell.2017.12.004

Figure 2.

Figure 2

WNT pathway alterations. (A) Alteration frequencies, types of alterations and alteration patterns of genes in the WNT pathway in MSI-H and MSS CRC cases. (B) A mutation in the intron upstream of exon 9 of APC introduces a splice acceptor site, which leads to a change in protein frame (left). Representative images of β-catenin immunohistochemistry in tumors with this APC splice variant (right). (C) Genomic alterations identified in CTNNB1 in MSI-H and MSS CRC cases and representative pictures of β-catenin immunohistochemistry in tumors with the indicated genotypes. Genomic alterations in exons 2–4 in the MSS CRC lollipop plot are shown in detail below, with in-frame deletions identified in CTNNB1 aligned to their start and stop sites. Bar graph shows relative frequency and spectrum of CTNNB1 alterations across tumor types, including hepatocellular carcinoma (HCC), endometrial carcinoma (UCEC), and skin cutaneous melanoma (SKCM). See also Figure S4.