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. 2018 Jan 12;13(1):e0190916. doi: 10.1371/journal.pone.0190916

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© 2018 Eyring et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — Betaine supplementation affected single carbon metabolites (A) HYCS, CYSTAT, and METH (not supplemented C57BL/6 black bars, supplemented C57BL/6 vertical striped bars, not supplemented C57Bl/6^Mthfr-/- white bars, supplemented C57BL/6^Mthfr-/- checkered bars). Betaine supplementation exacerbated the severity of HDM-induced allergic airway disease and abolished the effect of Mthfr loss. (B) Airway hyperresponsiveness (not supplemented HDM-treated C57BL/6^Mthfr-/- solid line closed circle, and supplemented C57BL/6^Mthfr-/- dashed line open circle and X), and (C) total cells, (D) eosinophils, (E) percentage of eosinophils in WLL. (F) Expression and (G) methylation of Tle4 is altered by betaine supplementation. (* p-value <0.05, ** p-value <0.01 *** p-value <0.001).