Fig 8. Amelioration of oxidative stress in rats with iohexol-induced nephrotoxicity treated with GKT137831.

Representative photomicrographs of immunostaining of renal 8-OHdG (8-hydroxy-2’-deoxygenase) at 24 h after intraperitoneal injection of iohexol in control mice or mice treated with iohexol with or without GKT137831 pretreatment. Image analysis of the extent and intensity of staining was performed. Data are presented as the mean ± SD (n = 4–5). **p < 0.01 versus the control and ^##p < 0.01 versus iohexol treatment only. Magnification, ×200; scale bar, 100 μm.