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. 2017 Jul 17;45(16):9694–9705. doi: 10.1093/nar/gkx613

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — SHAPE analysis of oncomiR-1. (A) SHAPE derived secondary structure model of oncomiR-1 cluster. The nucleotides are color coded according to SHAPE (font) and DMS (dot) reactivity. Solvent inaccessible nucleotides are shown in green circles. Pri-miRNA domains (P) and structural elements (H, helix; T, terminal loops) are indicated in the figure. Black arrows indicate Drosha cleavage sites. (B) Thermodynamic stability of all the helices constituting oncomiR-1 cluster. Free energy calculated using nearest neighbor analysis from the SHAPE derived model structure.