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. 2017 Jul 17;45(16):9694–9705. doi: 10.1093/nar/gkx613

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Modes by which tertiary structure of pri-miRNA influences differential processing of constituent miRNAs. (A) Pri-miRNA domains can have their basal helices (cyan segments) and/or Drosha cut sites buried, making them inaccessible to Drosha/DGCR8, impeding their microprocessing. Binding of a trans-acting factor is needed to unfold the tertiary structure to provide accessibility to Drosha. (B) In the fully folded structure, pri-miR-92a does not have a basal helix (dark blue segments). The binding of a trans-acting factor is necessary to generate a basal helix and make the primary microRNA domain a substrate for Drosha.