Table 1. The amino acid sequences of the peptides designed to inhibit RecA protein and theoretical and experimental estimates of their stability.
| Amino acid sequence (position # as in RecX from E. coli) | HC, % (theor.) | HC, % (exp.) | |
|---|---|---|---|
| #AA | 136-137-138-139-140-141-142-143-144-145-146-147-148-149-150-151-152-153 | ||
| RecX | Val-Phe-Ser-Glu-Lys-Val-Lys-Ile-Gln-Arg-Phe-Leu-Leu-Tyr-Arg-Gly-Tyr-Leu | 3.9 | N/S |
| 4E1 | Glu-Glu-Glu-Glu-Lys-Val-Lys-Ile-Leu-Arg-Tyr-Leu-Leu-Tyr-Arg-Leu-Ile-Tyr | 84.7 | 76 |
| Pep2 | Glu-Arg-Glu-Glu-Lys-Glu-Lys-Arg-Arg-Arg-Glu-Glu-Glu-Tyr-Arg-Arg-Arg-Met | 91.1 | 81 |
| Pep3 | Glu-Leu-Glu-Glu-Lys-Val-Lys-Arg-Leu-Arg-Glu-Glu-Leu-Tyr-Arg-Arg-Ile-Met | 84.9 | 81 |
| Pep4 | Glu-Glu-Glu-Glu-Lys-Arg-Lys-Arg-Leu-Arg-Glu-Glu-Leu-Tyr-Arg-Arg-Ile-Met | 93.1 | 86 |
RecX/#aa—the names and the position numbers of the RecX protein amino acid residues from E. coli. The amino acids that were fixed in the optimization are shown in bold.