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. 2018 Jan 12;13(1):e0191295. doi: 10.1371/journal.pone.0191295

Fig 8. Toxicity study on hematopoietic and lymphoid systems in mice.

Fig 8

Hematotoxicity dose response by Cu(II) complex was evaluated by examining spleens and bone marrows (femurs) of mice from the efficacy studies. Weight of spleens from HK1 mice (A) and C666-1-GFP-Luc2 mice (B) treated with different doses of Cu(II) complex. No significant difference was observed in spleen weight except in mice with C666-1 (5 and 6 mg/kg group). (C) Histological examination of spleens and femurs (upper panel, HK1 mice; lower panel, C666-1 mice) did not show any significant pathological changes in all the treatment groups (20x magnification). The values are expressed as mean ± SEM of 3–6 animals per group. *p<0.05 was considered as statistical significant.