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. 2018 Jan 12;13(1):e0191295. doi: 10.1371/journal.pone.0191295

Fig 9. In vivo efficacy study on HKI xenograft mice treated with Cu(II) complex.

Fig 9

Treatments were given via intraperitoneal injections and the regimes were as described in the Materials and Methods. (A) Tumor volume, (B) excised tumors (C) tissue weight and (D) mice body weight were compared between control and treatment groups. Treatment with Cu(II) complex was found to suppress / inhibit tumor growth and reduce tumor weight. No significant changes were observed in body weight and vital organs. (E) Histological examination of heart, liver, kidney and lung also did not show any significant pathological changes in all the groups (20x magnification). Values are expressed as mean ± SEM of 4–7 animals per group. *p<0.05 compared to control.