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. 2018 Jan 12;13(1):e0191295. doi: 10.1371/journal.pone.0191295

Fig 10. In vivo efficacy study on the EBV positive C666-1-GFP-Luc2 xenograft mice treated with Cu(II) complex.

Fig 10

(A) Tumor volume, (B) excised tumors and (C) tissue weight were compared between control and treatment groups. Only treatment with Cu(II) complex at 5 and 6 mg/kg were found to suppress/inhibit tumor growth and reduce tumor weight. No changes were observed in the weight of vital organs except for liver in the 6 mg/kg group. (D) Tumor treated with Cu(II) complex exhibited higher tumor necrotic percentage as compared to control groups. (E) Copper staining to stain for the presence of copper deposits in liver. (F) H&E staining of the major organs. Histological examination of heart, liver, kidney and lung did not show any significant pathological changes in all the groups (20x magnification). Values are expressed as mean ± SEM of 3–6 animals per group. *p<0.05 compared to control.