Table 2. IC50 values of CYP enzyme inhibition by Cu(II) complex and reference standards.
IC50 (μM) | |||
---|---|---|---|
CYP Isoform | Cu(II) complex | Reference standards (Drugs) | |
1A2 | 8.01 | 0.16 | (Fluvoxamine) |
2C9 | 8.56 | 0.16 | (Sulfaphenazole) |
2C19 | 10.26 | 1.47 | (Fluoxamine) |
2D6 | 10.23 | 0.43 | (Quinidine) |
2B6 | 7.59 | 0.10 | (Ticlopidine) |
2C8 | 10.32 | 0.31 | (Quercetine) |
3A4 | 5.46 | 0.05 | (Ketoconazole) |