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. 2018 Jan 12;13(1):e0191295. doi: 10.1371/journal.pone.0191295

Table 2. IC50 values of CYP enzyme inhibition by Cu(II) complex and reference standards.

  IC50 (μM)  
CYP Isoform Cu(II) complex Reference standards (Drugs)
1A2 8.01 0.16 (Fluvoxamine)
2C9 8.56 0.16 (Sulfaphenazole)
2C19 10.26 1.47 (Fluoxamine)
2D6 10.23 0.43 (Quinidine)
2B6 7.59 0.10 (Ticlopidine)
2C8 10.32 0.31 (Quercetine)
3A4 5.46 0.05 (Ketoconazole)