Table 3. Effects of Cu(II) complex on hematogical parameters in antitumor efficacy study on NPC.
| Treatment | |||||
|---|---|---|---|---|---|
| Unit | Control | 4 mg/kg | Control | 5 mg/kg | |
| RBC | (x1012/L) | 8.7 ± 0.2 | 7.8 ± 0.7 | 8.2 ± 0.3 | 7.8 ± 0.4 |
| Hemoglobin | (g/L) | 144.7 ± 2.9 | 126.8 ± 10.0 | 135.7 ± 4.3 | 133.7 ± 4.4 |
| PVC | (L/L) | 0.5 ± 0.0 | 0.4 ± 0.0 | 0.4 ± 0.0 | 0.4 ± 0.0 |
| MCV | (fL) | 53.0 ± 0.7 | 52.9 ± 1.2 | 52.9 ± 0.9 | 56.2 ± 1.8 |
| MCHC | (g/L) | 314.6 ± 4.5 | 308.5 ± 4.9 | 311.6 ± 4.1 | 308.3 ± 5.0 |
| WBC | (x109/L) | 2.2 ± 0.4 | 2.5 ± 0.5 | 2.3 ± 0.2 | 2.9 ± 0.3* |
| Band neutrophil | (x109/L) | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| Segmented neutrophil | (x109/L) | 1.7 ± 0.3 | 2.0 ± 0.4 | 1.8 ± 0.2 | 2.5 ± 0.2* |
| Lymphocytes | (x109/L) | 0.1 ± 0.0 | 0.2 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| Monocytes | (x109/L) | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 | 0.2 ± 0.0 |
| Eosinophils | (x109/L) | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Basophils | (x109/L) | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Thrombocytes | (x109/L) | 1353.7 ± 45.2 | 1659.0 ± 120.4 | 1506.3 ± 63.3 | 1288.2 ± 155.8 |
| Plasma protein | (g/L) | 65.3 ± 2.7 | 59.5 ± 2.2 | 62.4 ± 2.6 | 55.7 ± 2.5 |
The values were from the efficacy study on mice bearing C666-1-GFP-Luc2 xenograft. Data are expressed as mean ± SEM (group 4 mg/kg Cu(II) complex, n = 3–4; group 5 mg/kg, n = 6). Data for group 6 mg/kg Cu(II) complex was excluded due to insufficient sample size number of animals where only one out of four mice, had survived in the Cu(II) complex treated group.
*p<0.05 was considered significant using t-test. Asterisks denote significant difference compared to control.
Abbreviations: MCV, mean corpuscular volume; MCHC, mean corpuscular Hb concentration.