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. 2018 Jan 12;13(1):e0191203. doi: 10.1371/journal.pone.0191203

Fig 6. Effects of tomato extract, 9-oxo-ODA, and daphnetin on JNK, ERK, and p38 phosphorylation, and IκB-α degradation in RAW264.7 macrophages stimulated with LPS.

Fig 6

RAW264.7 cells were stimulated with LPS (100 ng/mL) and incubated with tomato extract, 9-oxo-ODA, or daphnetin for 1 h. Total cell lysates were extracted from cultured RAW264.7 cells. Effect of (A) tomato extract, (B) 9-oxo-ODA, and daphnetin on phosphorylated JNK, ERK, and p38, and IκB-α degradation. (C) Schematic illustration of the mechanism of inhibition of pro-inflammatory mediators by tomato extract, 9-oxo-ODA, and daphnetin.