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. 2018 Jan 2;14(1):e1006789. doi: 10.1371/journal.ppat.1006789

Fig 9. The proposed model to show how TLCYnV C4 interferes with the cell cycle in mature leaves through changing the nuclear-localization of NbSKη.

Fig 9

TLCYnV C4 directs NbSKη to the cyto-membrane and reduces the accumulation of nucleus-localized NbSKη. The redistribution of NbSKη mediated by C4 interrupts the phosphorylation and proteasomal degradation of nucleus-located NbCycD1;1, and then increases the accumulation level of NbCycD1;1. Increased accumulation of NbCycD1;1 induces the callus-like tissues formation and creates an environment suitable for DNA virus replication in mature and differentiated leaves.