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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Cancer. 2017 Oct 17;126(1):44–53. doi: 10.1002/cncy.21934

Figure 2.

Figure 2

Examples of cases where 3 reviewers agreed (a–d), disagreed (e–g), or could not reach consensus on differentiation (h–j). (a) A G3 PanNET (Ki67 30%) agreed upon as WD (ThinPrep) (b) All three reviewers agreed this was PD-L. There are large cells, abundant cytoplasm, and necrosis (ThinPrep) (c) All three reviewers agreed on PD-S for this neoplasm with small cells, minimal cytoplasm, and apoptosis. (ThinPrep) (d) The reviewers agreed this case was PD but could not agree on small versus large cell type. (ThinPrep) (e) Reviewers did not agree on differentiation for this case but final classification was WD based on DAXX and MEN1 mutations. (f) Reviewers did not agree on differentiation and Rb was retained by immunohistochemistry which was not helpful. Final classification by consensus was PD. (g) Reviewers did not agree on this case, but final classification was WD based on prior a history of resected PanNET G1/G2. (h–j). Consensus was not reached for differentiation on these cases which had supporting data for tumor biology, so they were not classified. ((h) Case 5, ThinPrep) ((i) Case 5, Diff Quik 40x) ((j) Case 9, Diff Quik).