Table 6.
Analysis for which cytologic features correlated with reviewer agreement in the well differentiated neoplasms
| Final classification* | Well differentiated N=55 |
P value | |
|---|---|---|---|
| Consensus agreement by all 3 reviewers | Yes | No | |
| N (%) | 16 (30) | 39 (70) | |
| Grade | |||
| G2 ** | 5 | 8 | |
| G3** | 3 | 9 | |
| Ki67 median (range) | 20.5 (3.2–68) | 32.5 (5–89) | 0.1 |
| Large nuclear size | 0 | 2 | 0.9 |
| Nuclear size variation | 0.06 | ||
| Uniform | 9 | 10 | |
| Non-uniform | 7 | 25 | |
| Pleomorphic | 0 | 4 | |
| Nucleus shape | 0.03 | ||
| Round | 14 | 21 | |
| Ovoid | 2 | 18 | |
| Nucleus contour | 0.9 | ||
| Smooth | 15 | 36 | |
| Irregular | 1 | 3 | |
| Angulated nuclei | 1 | 15 | 0.02 |
| Chromatin | 0.7 | ||
| Fine | 1 | 5 | |
| Coarse | 13 | 27 | |
| Single prominent nucleolus | 0 | 5 | 0.3 |
| Plasmacytoid cells | 15 | 26 | 0.03 |
| Nuclear tangles | 8 | 27 | 0.2 |
| Molding | 1 | 6 | 0.7 |
| Apoptosis | |||
| Any | 9 | 35 | 0.009 |
| >5/10 hpf | 2 | 19 | 0.01 |
| Mitoses | |||
| Any | 6 | 25 | 0.1 |
| >5/10 hpf | 0 | 9 | *** |
| Necrosis | 0 | 6 | 0.2 |