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. Author manuscript; available in PMC: 2019 Jan 11.
Published in final edited form as: Cell. 2018 Jan 4;172(1-2):234–248.e17. doi: 10.1016/j.cell.2017.12.001

Figure 2. Physiologic leptin replacement reduces WAT lipolysis and hepatic gluconeogenesis in 48 hr fasted rats, but supraphysiologic leptin reverses this effect by stimulation of catecholamine secretion.

Figure 2

(A)–(B) Plasma leptin and glucose concentrations during a 6 hr infusion of stepwise increasing doses of leptin in 48 hr fasted rats. (C) Whole-body glucose turnover. (D)–(F) Plasma corticosterone, epinephrine and norepinephrine concentrations. (G)–(H) Whole-body fatty acid and glycerol turnover. (I) Liver acetyl-CoA content. (J) Whole-body β-OHB turnover. In all panels, n=8. Paired comparisons (ANOVA with Bonferroni’s multiple comparisons test) were performed. Data are the mean±S.E.M. See also Fig. S3.