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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Pediatr Blood Cancer. 2017 Nov 1;65(3):10.1002/pbc.26871. doi: 10.1002/pbc.26871

TABLE 2.

Treatment-related toxicities by ethnicity during induction and post-induction therapy

Induction Toxicity Ethnicity p-value
Entire Cohort Hispanic Non-Hispanic

No. % No. % No. %
All 730 - 150 - 580 - -

Infection 203 28 37 25 166 29 0.36
 Bacterial 183 25 29 19 154 27 0.07
 Fungal 30 4 8 5 22 4 0.36
 Viral 5 <1 1 1 4 1 1.00
 Opportunistic 3 <1 1 1 2 0 -

Asparaginase toxicity 47 6 10 7 37 6 0.85
 Pancreatitis 17 2 6 4 11 2 0.13
 Allergy 10 1 2 1 8 1 1.00
 Thrombosis 20 3 2 1 18 3 0.40

Bone Event 3 <1 3 1 0 0 -
 Bone Fracture 3 <1 3 1 0 0 -
 Osteonecrosis 0 <1 0 0 0 0 -

Post-Induction Toxicity Ethnicity p-value
Entire Cohort Hispanic Non-Hispanic

No. % No. % No. %

All 690 - 140 - 550 - -

Infection 220 32 44 31 176 32 0.92
 Bacterial 158 23 30 21 128 23 0.74
 Fungal 17 2 2 1 15 3 0.55
 Viral 59 9 17 12 42 8 0.09
 Opportunistic 21 3 1 1 20 4 0.10

Asparaginase toxicity 183 27 40 29 143 26 0.59
 Pancreatitis 75 11 20 14 55 10 0.17
 Allergy 63 9 14 10 49 9 0.74
 Thrombosis 72 10 11 8 61 11 0.35

Bone Event* 163 24 15 11 148 27 <0.0001
 Bone Fracture 131 19 11 8 120 22 <0.0001
 Osteonecrosis 54 8 4 3 50 9 0.013
*

Only includes bone toxicity on therapy